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Staphylococcal Meningitis Following Pneumoencephalography

Ann Intern Med. 1962;57(1):128-132. doi:10.7326/0003-4819-57-1-128
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There has been a startling and well-documented increase in the morbidity and mortality from staphylococcal infections since the advent of the antibiotic era. Staphylococcal meningitis, a grave but still relatively uncommon disease, offers no exception to this trend (1). Recent large series have incriminated Staphylococcus aureus as the causative agent in 0.3 per cent to 7.8 per cent of all pyogenic meningitides (2-5).

Prior to 1941, staphylococcal meningitis was almost uniformly fatal. Indeed, from 1893 through 1941, there were only 48 documented cases of recovery from this disease reported in the world literature (6). Bacteriophage (7), sulfonamide, and particularly antibiotic


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