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History of Medicine |

An Historical Account of the Study of Progressive Systemic Sclerosis (Diffuse Scleroderma)

Ann Intern Med. 1962;57(2_Part_1):305-319. doi:10.7326/0003-4819-57-2-305
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Rien n'est plus bizarre, mais aussi rien n'est plus intéressant que la dégénération cornée du systême dermoïde. Elle sera toujours pour les médecins un grand sujet d'étude et de méditation, tant qu' ils ajouteront quelque prix aux recherches physiologiques.

—Alibert, 1818 (1)

Progressive systemic sclerosis (diffuse scleroderma) is now recognized to be a widespread disturbance of connective tissue with characteristic involvement of the skin (scleroderma), synovium, and various internal organs, particularly the heart, lung, gastrointestinal tract, and kidney (2-12). The present paper is concerned with both the rather long history of scleroderma and with the recognition of the systemic nature


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