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The Relationship of the Juxtaglomerular Apparatus to Sodium Retention in Experimental Nephrosis

Ann Intern Med. 1962;57(3):382-388. doi:10.7326/0003-4819-57-3-382
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Whenever rats, dogs, or cats are given a sodium deficient diet for a month or 2, the granules in the cytoplasm of juxtaglomerular cells become much more abundant, and the cells themselves often become hyperplastic (1, 2). The opposite effect is seen in rats when a diet containing 7.4 per cent sodium chloride is used. When rats eat these large quantities of salt, the granularity of the juxtaglomerular cells diminishes (3). The actual sodium concentration in the extracellular fluid is scarcely changed by these variations in sodium intake. Hence, attention is focused on changes in extracellular fluid volume or blood


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