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Acid Hyperphenylphosphatasia in Thrombophlebitis and Pulmonary Embolism

Ann Intern Med. 1962;57(3):468-471. doi:10.7326/0003-4819-57-3-468
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Erythrocytes and platelets are rich in acid phosphatase (1-4). Therefore, it occurred to us that perhaps the destruction of blood cells enmeshed within the blood clots of patients with thrombo-embolic diseases would release into the serum sufficient quantities of the enzyme to be of diagnostic value. We chose to measure acid phenylphosphatase activity, mainly because we had had extensive experience with the required chemical techniques. The results of our preliminary observations on patients with thrombophlebitis or pulmonary embolism are presented below. Studies on cases of coronary thrombosis, cerebral thrombosis, and systemic embolization are in progress and will be reported at


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