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Upper Respiratory Illness Vaccines: Perspectives and Trials

Ann Intern Med. 1962;57(4):526-537. doi:10.7326/0003-4819-57-4-526
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The story of immunization for prevention of upper respiratory illnesses began during the second World War with influenza virus vaccines (1). Additions to the antigenic components and refinements in preparation and inactivation of the viruses derived from growth in the allantoic sac of the embryonated egg followed. Except for the prophylactic application of antibiotics for streptococcal pharyngitis little was added to the measures used for prevention of upper respiratory illnesses prior to isolation of the adenoviruses and development of vaccines from viruses propagated in tissue culture (2). Only types 3, 4, and 7 have been included because these adenoviruses have




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