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The Prognosis of Ulcerative Colitis with Onset in Childhood: I. The Pre-Steroid Era

Ann Intern Med. 1962;57(4):582-591. doi:10.7326/0003-4819-57-4-582
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In a disease of unknown etiology with high morbidity and mortality such as ulcerative colitis, an accurate appraisal of the true value of new medical and surgical techniques must be predicated on more than a statistical comparison with the results of earlier methods of treatment. Proper evaluation of such data requires, in addition, a well-documented conception of the history of the disease uninfluenced by the use of these new agents, particularly when the clinical course is very prone to variations. When ulcerative colitis begins in childhood, interference with growth and development is added to the long list of complications which


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