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The Prognosis of Ulcerative Colitis with Onset in Childhood: II. The Steroid Era

Ann Intern Med. 1962;57(4):592-597. doi:10.7326/0003-4819-57-4-592
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It has been determined in a preceding long-term study of the pre-steroid era that the prognosis of ulcerative colitis with onset in childhood is poor (1). If we utilize this "natural history" of the disease for comparison, the influence of steroids on ulcerative colitis in this age group may now be evaluated. Perplexing problems, such as the adequacy of prolonged medical control of the disease with steroids and the influence of these agents on complications, definitive surgery, and mortality, may be answered in part. The important question of early versus late surgical intervention, with the employment of steroids as a


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