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Treatment of Breast Cancer with 5-Fluorouracil

Ann Intern Med. 1962;57(4):598-605. doi:10.7326/0003-4819-57-4-598
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The role of 5-fluorouracil in the chemotherapy of breast cancer has yet to be accurately defined. That it is useful and effective in some cases is beyond doubt, but its associated toxicity renders it a formidable agent to use.

For some years, metabolic differences between normal and neoplastic tissues have been sought with the hope that such differences could be exploited by chemotherapeutic agents. Both Rutman (1) and Heidelberger (2), with their co-workers, have observed that uracil may be preferentially utilized for synthesis of nucleic acid in certain neoplastic tissues. Consequently, several altered molecules of uracil were synthesized and their


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