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Farmer's Lung: Physiopathologic Features of the Acute Interstitial Granulomatous Pneumonitis of Agricultural Workers

JOHN RANKIN, M.D., M.R.C.P.; WALTER H. JAESCHKE, M.D.; QUINTON C. CALLIES, B.S.; and HELEN A. DICKIE, M.D., F.A.C.P.
Ann Intern Med. 1962;57(4):606-626. doi:10.7326/0003-4819-57-4-606
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We have previously described the clincal features of an acute granulomatous interstitial pneumonitis that occurred in 39 agricultural workers after exposure to moldy organic farm dusts (1). Thirty-four additional patients have been studied since 1958. The present report concerns the pathologic features demonstrated by lung biopsy and the close correlation of the histologic evidence with our concept of the pathologic physiology and natural history of the disease. Moreover, we now believe that a diagnosis can be established with certainty without the aid of lung biopsy and that, except in rare instances, we are no longer justified in subjecting the patient

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