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Large Doses of Prednisone and Prednisolone in the Treatment of Malignant Lymphoproliferative Disorders

ROBERT A. KYLE, M.D.; CLIFTON E. MCPARLAND, M.D.; and WILLIAM DAMESHEK, M.D., F.A.C.P.
Ann Intern Med. 1962;57(5):717-731. doi:10.7326/0003-4819-57-5-717
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Treatment of the generalized chronic malignant lymphoproliferative disorders* is not standardized at all. In asymptomatic chronic lymphocytic leukemia, the best treatment is often no treatment. In the "aggressive" cases of chronic lymphocytic leukemia (1) and in generalized or disseminated lymphosarcomatosis, one of several therapeutic programs may be preferred. These include treatment with roentgen rays, nitrogen mustard, or one of the other alkylating agents [triethylene melamine (TEM), chlorambucil (Leukeran), or cyclophosphamide (Cytoxan)]; and corticosteroids. Each form of therapy has its adherents, and each may be said to have a special value in some phases of the patient's illness. In the last

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