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A Cryo-precipitating Factor

Ann Intern Med. 1962;57(5):810-819. doi:10.7326/0003-4819-57-5-810
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In 1933 Wintrobe and Buell (1) described a cold precipitable globulin in the serum of a patient with multiple myeloma. The term cryoglobulin was introduced by Lerner and Watson (2) to describe proteins with this abnormal physical characteristic. Korst and Kratochvil (3) reported a protein that clotted and had many other physical and chemical properties similar to those of fibrinogen. It also exhibited the property of reversible precipitation on chilling, and the designation cryofibrinogen was suggested. These proteins have been noted in many disease entities, and recent reports (4-10) have adequately reviewed the literature. The physicochemical and immunological characteristics of


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