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A Urinary Cryoprotein in Multiple Myeloma

Ann Intern Med. 1962;57(5):819-823. doi:10.7326/0003-4819-57-5-819
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Multiple myeloma is characteristically associated with one or more of 3 distinct abnormalities in protein metabolism: (a) the production of abnormal serum globulins (myeloma globulins); (b) urinary excretion of Bence Jones protein; and (c) deposition in the tissues of a protein known as paramyloid (primary amyloid). In a small percentage of cases of multiple myeloma, a cold-precipitable protein of the serum has been identified and termed a cryoglobulin (1). The purpose of this report is to present a case of multiple myeloma associated with the urinary excretion of a unique paraprotein with the combined properties of "cryoglobulin" and a Bence


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