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Circulating Plasma Cells in Multiple Myeloma: A Method for Detection and Review of the Problem

DONALD M. GINSBERG, M.D.
Ann Intern Med. 1962;57(5):843-846. doi:10.7326/0003-4819-57-5-843
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Since bone marrow aspirations and the use of electrophoretic patterns of the serum and urine have simplified the diagnosis of multiple myeloma, the search for plasma cells in peripheral blood smears is rarely attempted. It is the purpose of the paper to: [1] describe how these cells may be detected in venous blood with a simple method derived from the work of Moore, Sandberg, and Schubarg (1), and [2] to discuss the relevant literature concerning the presence of the plasma cells in peripheral smears.

MATERIAL: Eighteen patients with diagnoses of multiple myeloma and no evidence of plasma cell leukemia were

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