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Nephrotic State as the Chief Manifestation of Systemic Lupus Erythematosus

Ann Intern Med. 1962;57(6):981-987. doi:10.7326/0003-4819-57-6-981
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The nephrotic syndrome as the chief manifestation of systemic lupus erythematosus (SLE) is rare (1-3). The present report describes the course of illness in 2 patients who were thought to have a nephrotic state with most of the features of "pure nephrosis" (4, 5). In neither case was the presence of systemic lupus erythematosus suspected while the patients were still alive; the diagnosis was established by post-mortem examination.


CASE 1: The patient, an 18-year-old Negro boy, was first seen in the outpatient clinic at the University of California Medical Center in February 1958, because of orchido-epididymitis, for which


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