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Pathology of Fatal Bacterial Endocarditis before and since the Introduction of Antibiotics

Ann Intern Med. 1963;58(1):84-92. doi:10.7326/0003-4819-58-1-84
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The occurrence, prognosis, and clinical course of many severe bacterial infections have been greatly improved with the development of effective antimicrobial agents. There is well-documented evidence that with these drugs has come a change in bacterial flora within the population, as well as an alteration in the etiologic organisms of several specific infectious entities (1-3).

In view of this shift in etiology, it would seem reasonable to ask if there has been a corresponding change in the pathology of the specific infectious diseases since the introduction of antibiotics. Kneeland and Price have shown that the organisms formerly considered to be


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