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The Heart in Rheumatoid Arthritis (Rheumatoid Disease): A Clinical and Pathological Study of Sixty-two Cases

Ann Intern Med. 1963;58(1):102-123. doi:10.7326/0003-4819-58-1-102
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The systemic nature of rheumatoid arthritis is emphasized by the occurrence of lesions in many tissues other than those of joints (1-3). The heart, in particular, is frequently involved (4-8), and 2 groups of lesions have been described in this organ. These are: [1] rheumatoid granulomata, and [2] non-specific inflammatory lesions. Little doubt exists about the rheumatoid etiology of the granulomata, but there has been disagreement as to the interpretation of the non-specific lesions. Although earlier writers tended to ascribe these lesions to rheumatic heart disease (6-8), more recent investigators have suggested that these lesions are manifestations of the rheumatoid


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