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Serum Iso-amylases: An Electrophoretic Study of the Blood Amylase and the Patterns Observed in Pancreatic Disease

Ann Intern Med. 1963;58(2):235-244. doi:10.7326/0003-4819-58-2-235
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We have recently summarized the evidence that the amylase of the serum is of heterogenous origin (1). Studies in this laboratory on the regulation of blood amylase levels (2, 3) have shown that [1] normal blood amylase is controlled in part at extrapancreatic sites, [2] blood amylase is lowered in states of increased carbohydrate utilization, and [3] the amylase responses to alterations of carbohydrate metabolism are markedly altered by liver disease but unaffected by total pancreatectomy. These findings led to the conclusion that the liver contributes to the blood amylase level and is an important site of regulation. Similar conclusions


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