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The Present Status of ACTH Therapy in Multiple Sclerosis

Ann Intern Med. 1963;58(3):454-471. doi:10.7326/0003-4819-58-3-454
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Many investigators have used adrenocorticotrophic hormone (ACTH) in the treatment of multiple sclerosis. Information being accumulated clearly delineates the effectiveness of such treatment in this kind of progressive disease. In a series of 43 patients treated with ACTH, 18 of whom were compared with controls matched by age, sex, duration of illness, and disability score at the time of treatment and over the preceding 3 to 12 months, the degree of improvement, evaluated in terms of a pre-established scoring system, was found to be statistically significant (1, 2). In a study by Miller, Newell, and Ridley (3) a similar dosage


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