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Gout and Glycogen Storage Disease

H. EDWARD HOLLING, M.D., F.R.C.P.
Ann Intern Med. 1963;58(4):654-663. doi:10.7326/0003-4819-58-4-654
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This report completes the clinical account of a brother and 2 sisters who now have been reported 3 times, each time under a different diagnosis. They were first described in 1926 by Poynton and Wyllie (1) as examples of familial cirrhosis. This diagnosis was corrected in 1936 when they were again described in an account of glycogen storage disease of the liver by Ellis and Payne (2). Two of them are now presented as examples of gout associated with glycogen storage disease.

All 3 patients appear to have had the form of glycogen storage disease in which the glucose-6-phosphatase activity

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