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Dilution Anemia Corrected by Splenectomy in Gaucher's Disease

A. J. BOWDLER, M.B., B.SC., M.R.C.P.
Ann Intern Med. 1963;58(4):664-669. doi:10.7326/0003-4819-58-4-664
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This excerpt has been provided in the absence of an abstract.

Gaucher's disease is commonly accompanied. by anemia, which is usually ascribed to the replacement of bone marrow by colonization with the cerebroside-laden Gaucher cells; occasionally it may be due to hemorrhages conditioned by thrombocytopenia, and very rarely there has been described an associated acquired hemolytic anemia (1, 2).

The present case illustrates a further mechanism by which the level of circulating hemoglobin may be depressed in this disease: the total circulating red cell mass was within normal limits, but the plasma volume (and thus the total blood volume) was greatly expanded, so that anemia arose from the dilution of the


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