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Bronchogenic Carcinoma Associated with Severe Orthostatic Hypotension

Ann Intern Med. 1963;58(4):669-676. doi:10.7326/0003-4819-58-4-669
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Orthostatic hypotension may be idiopathic or secondary to various diseases of the nervous system (1-5), including diabetic neuropathy, (6) or to adrenocortical insufficiency, hypokalemia, renal amyloidosis (7), and porphyria (8). In spite of the recent interest in systemic manifestations of malignant tumors (9, 10), and particularly in the various forms of carcinomatous neuropathies (11-13), only one instance of orthostatic hypotension associated with carcinoma was found in the literature (14), and in that case renal sodium wastage and hyponatremia were a prominent part of the clinical picture.

Although in the following case necropsy was unobtainable, a pathogenetic relationship between tumor and


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