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The Effect of Inspiration of Cold Air on the Electrocardiogram of Normal Dogs, Normal Humans, and Humans with Angina Pectoris.

M. J. Murray, M.D., F.R.A.C.P.
Ann Intern Med. 1963;58(4):712. doi:10.7326/0003-4819-58-4-712_3
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Angina pectoris may be precipitated by exposure of subjects to cold air. This study was designed to decide whether angina resulted from inhalation of cold air rather than from external contact with it. Normal anesthetized dogs were allowed to inhale air with a mouth delivery temperature of -10 F from a positive pressure breathing apparatus. Electrocardiograms were recorded continuously. Despite a 5-F fall in temperature of left atrial blood recorded by a thermistor, there were no significant electrocardiographic changes. Twelve young healthy males, with normal resting electrocardiograms, inhaled air with a delivery temperature of -10 F from a similar machine.

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