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The Mechanism of Action of Metaraminol (Aramine).

C. A. Chidsey, M.D.; D. L. Harrison, M.D.; and E. Braunwald, M.D., F.A.C.P.
Ann Intern Med. 1963;58(4):713. doi:10.7326/0003-4819-58-4-713_1
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The mechanism of action of metaraminol, a vasopressor widely employed today in clinical practice, has not been precisely defined. The present study was carried out to investigate this problem in open-chest anesthetized dogs. The response of systolic arterial pressure and right ventricular contractile force, recorded with a Walton-Brodie strain gauge arch, to various doses of metaraminol was measured in 4 reserpine-pretreated, catecholamine-depleted dogs and in 4 control dogs. The increase in contractile force produced by 30 μg/kg metaraminol was decreased from an average of 125% in the control to 22% in the amine-depleted animals. Similar reductions in the pressor


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