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Abstracts |

Clinical Problems Arising from the Laboratory Control of Anticoagulant Therapy.

B. H. Pastor, M.D., F.A.C.P.; and T. Rodman, M.D., F.A.C.P.
Ann Intern Med. 1963;58(4):713-714. doi:10.7326/0003-4819-58-4-713_3
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The aboratory control of anticoagulant therapy presents many complex problems of major clinical importance. The most perplexing of these is the lack of exact knowledge concerning the factor or factors which must be regulated to prevent intravascular thrombosis or undesirable bleeding. Without this precise information the clinician is dependent upon tests which reflect those factors known to be concerned in the clotting mechanism and presumed to be of importance in clinical anticoagulation. The clinician's problem is further compounded by the variety of tests available and by laboratory inaccuracies which may lead either to inadequate therapy or to serious hemorrhagic complications.

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