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Myocardial Metabolism Studied in the Isolated Perfused Rat Heart with Radioisotopes: Importance of Free Fatty Acids.

J. C. Shipp, M.D.; L. H. Opie, M.D.; O. E. Matos, B.S.; and L. Crevasse Jr., M.D. (Associate)
Ann Intern Med. 1963;58(4):716. doi:10.7326/0003-4819-58-4-716_2
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This approach permits a direct study of the uptake and cellular fat of a particular substrate. The uptake of free fatty acid and glucose, lactate production, residual and labeled heart glycogen, and the amount of label appearing in CO2 and in tissue fatty acids were measured. When present alone, the uptake of glucose-u-C14 and of palmitate-1-C14 was a linear function of concentration over the physiologic range. Each was promptly oxidized to CO2. Glucose was incorporated into glycogen, and a significant fraction appeared as lactate. Palmitate was also present as tissue fatty acids; when combined, fatty acid was oxidized in preference

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