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Abstracts |

Crystal Induced Inflammation—Syndromes of Gout and Pseudogout.

D. J. McCarty Jr., M.D. (Associate)
Ann Intern Med. 1963;58(4):717. doi:10.7326/0003-4819-58-4-717_1
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Sodium urate crystals have been identified by polarized light microscopy in virtually all (59 of 60) aspirates from gouty joints; their presence is thought to be pathognomonic of gout. Injection (by ourselves and others) of these and other microcrystals of various chemical composition into human and canine joints has resulted in an acute inflammatory response. This response is a non-specific host reaction to sparingly soluble micro-crystals, characterized by phagocytosis of the offending particles by leukocytes and by complete reversibility when these particles have been removed.

Five routes to hyperuricemia have been suggested; regardless of the original mechanism of hyperuricemia, the


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