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Abstracts |

Intensive Therapy of Wilson's Disease.

I. H. Scheinberg, M.D.; and I. Sternlieb, M.D.
Ann Intern Med. 1963;58(4):717. doi:10.7326/0003-4819-58-4-717_2
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Evidence has been accumulated in the past several years indicating that Wilson's disease is synonymous with chronic human copper toxicity and that intensive removal of copper from patients results in improvement in the symptoms and signs of the disease. We have previously presented findings to this audience which indicated that gradual removal of copper is generally accompanied by slow clinical amelioration, particularly of the neurologic manifestations of the illness.

With the availability of plentiful supplies of D-penicillamine, and the addition of injections of BAL to the regimen, it has become possible to effect removal of significant amounts of copper in


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