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Abstracts |

The States of Copper in Serum.

I. H. Scheinberg, M.D.; C. J. A. van den Hamer, Ph.D.; A. G. Morell, M.S.; and J. Windsor, B.S.
Ann Intern Med. 1963;58(4):719. doi:10.7326/0003-4819-58-4-719_1
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In normal healthy adults each milliliter of serum contains close to 1 μg of copper. Almost all of this is present as an integral part of the molecule of ceruloplasmin, a copper-protein of serum. There is a small portion, about a tenth, of the total serum copper that is not part of ceruloplasmin and that is probably loosely bound to albumin.

A precise and accurate determination of the non-ceruloplasmin copper of serum is difficult, since it represents the relatively small difference between total serum copper and ceruloplasmin-copper. We have attempted to analyze, for copper, the supernatant portion of samples of

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