The full content of Annals is available to subscribers

Subscribe/Learn More  >
Abstracts |

Biologic Rhythms in Hyperthyroidism.

D. H. Mintz, M.D.; M. M. Martin, M.D.; J. J. Canary, M.D.; and D. Hellman, M.D.
Ann Intern Med. 1963;58(4):719. doi:10.7326/0003-4819-58-4-719_2
Text Size: A A A
This excerpt has been provided in the absence of an abstract.

Hyperthyroroism is known to increase 24-hour urinary 17-hydroxycortico-steroid (17OHCS) as well as inorganic phosphate excretion. The observation that forenoon phosphate clearance, in contrast, was reduced in hyperthyroidism prompted a study of the circadian variation in serum and urinary inorganic phosphate, and plasma and urinary 17OHCS.

Hyperthyroidism, by accelerating steroid degradation and excretion, lowers plasma free 17OHCS and exaggerates the rhythm in plasma conjugated and total urinary 17OHCS. The lack of significant variation in cortisol half-life and minimal differences in adrenal stimulation by exogenous ACTH at different times throughout 24 hours appear to exclude changes in adrenal responsiveness or peripheral steroid


First Page Preview

View Large
First page PDF preview





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $42.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Related Point of Care
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.