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John Phillips Memorial Lecture: Observations on Metabolism of Aldosterone in Man.

John A. Luetscher, M.D.
Ann Intern Med. 1963;58(4):719. doi:10.7326/0003-4819-58-4-719_3
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The circulating level of aldosterone reflects the balance between rate of secretion by the adrenals and metabolic clearance rate by the liver. Although the concentration of aldosterone in plasma is too low to be measured accurately, the mean plasma level can be calculated. Secretion rate is estimated from measured specific activity of a purified metabolite after injection of labeled aldosterone. In most instances, the quantity released from strongly acidified urine serves as a fair index of secretion rate; but in pregnancy, renal insufficiency, or hepatic cirrhosis, the fraction of secreted aldosterone metabolized to this form is abnormal. Metabolic clearance rate


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