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Abstracts |

Clinical Significance of Urinary Hydroxyproline.

T. A. Dull, M.D.; and P. H. Henneman, M.D.
Ann Intern Med. 1963;58(4):720. doi:10.7326/0003-4819-58-4-720_2
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The Imino Acid hydroxyproline occurs in the body almost exclusively in collagen. Twenty-four-urinary total hydroxyproline was measured in 57 subjects on diets devoid of gelatin. Eight normal adults excreted 8 to 40 mg daily, and 15 adults with various diseases not known to involve connective tissue excreted from 8 to 37 mg of total hydroxyproline daily. Eight normal prepubertal children excreted 30 to 103 mg, while 5 children with growth failure excreted 21 to 42 mg daily. Urinary hydroxyproline in 6 hyperthyroid patients ranged from 79 to 440 mg, and in 15 patients with Paget's disease, values from 67 to


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