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Abstracts |

Aspirin Induced Suppression of Paget's Disease of Bone.

P. H. Henneman, M.D.; P. F. Maurice, M.D.; L. V. Avioli, M.D.; T. A. Dull, M.D.; C. H. Bastomsky, M.D.; and T. N. Lynch, M.D.
Ann Intern Med. 1963;58(4):720-721. doi:10.7326/0003-4819-58-4-720_3
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A has been administered to tolerance for 3 to 27 days during complete balance studies on 6 patients with Paget's disease of bone. Within 3 days, there has occurred a decrease in serum, urinary, and fecal calcium with resultant calcium retention. Phosphorus retention resulted from a decrease in fecal excretion despite a slight increase in urinary phosphorus. Although fasting levels of serum magnesium were unchanged, urinary and fecal magnesium decreased with resultant magnesium retention. Calcium47 kinetic analyses in 4 patients revealed increased exchangeable calcium pools, endogenous fecal calcium, and bone resorption and formation rates. Following administration of aspirin, there was


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