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Abstracts |

Kinetics of Pituitary ACTH Secretion in Man.

E. M. Gold, M.D.
Ann Intern Med. 1963;58(4):721. doi:10.7326/0003-4819-58-4-721_2
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ACTH is now detectable in peripheral human plasma at concentrations as low as 0.5 mU/ 100 ml, utilizing sensitive bioassay techniques currently available. Normal resting levels of ACTH in man range from less than 0.5 to 1.2 mU/100 ml at plasma corticosteroid (PSC) concentrations of 10 to 20 μg/100 ml. Acute myocardial infarction and hypoglycemia, while associated with three- to sixfold increases in PSC, produce little change in plasma ACTH. Only slight rises in circulating ACTH titers, amounting to less than 0.5 mU/100 ml, apparently suffice to elevate PSC levels markedly. The lowest rate of pituitary ACTH secretion required to


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