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Human Growth Hormonelike Activity of Ovine Prolactin in Man.

J. C. Beck, M.D., F.A.C.P.; and E. E. McGarry, M.D., F.A.C.P.
Ann Intern Med. 1963;58(4):722. doi:10.7326/0003-4819-58-4-722_3
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Growth hormone preparations from other than primate sources are biologically inactive in man. Recent chemical, biological, and immunological evidence suggests that human growth hormone is identical or similar to human prolactin. Therefore, the metabolic effect of a purified sheep prolactin preparation was studied in man. Three hypopituitary dwarfs on metabolic balance study were given human growth hormone and, subsequently, sheep prolactin. The sheep prolactin preparation was found to mimic the metabolic action of human growth hormone, producing nitrogen retention, hypercalciuria, and relative impairment of carbohydrate tolerance. One 18-year-old female with a bone age of 12 years and a prepubertal body



sheep ; prolactin

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