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Abstracts |

Tests of Pituitary ACTH Secretory Capacity.

N. M. Kaplan, M.D. (Associate)
Ann Intern Med. 1963;58(4):723. doi:10.7326/0003-4819-58-4-723_1
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Metopirone (SU-4885) has been widely used as a test of pituitary ACTH reserve. Problems in the interpretation of the test remain, both in the definition of the normal response and in the meaning of the abnormal response.

A comparison was made between the urine and plasma levels of both 17-hydroxycorticoids (Porter-Silber chromogens) and 11-desoxycorticosteroids (11-DOCS) in healthy subjects and patients with and without pituitary disease. The response to Metopirone could be interpreted best by the changes in urine 11-DOCS excretion, the normal response being a rise of at least 7 mg/day above the control level. The use of P-S chromogen


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