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Effects of Dextrorotatory Triiodothyronine (D-T-3) on Lipid Metabolism in Human Subjects.

S. D. Splitter, M.D. (Associate); M. B. Fine, M.D.; G. D. Michaels, Ph.D.; and L. W. Kinsell, M.D., F.A.C.P.
Ann Intern Med. 1963;58(4):723. doi:10.7326/0003-4819-58-4-723_2
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This excerpt has been provided in the absence of an abstract.

Recent publications indicate that thyroid and thyroid-like substances lower the level of plasma lipids and suggest that dextrorotatory isomers of some iodinated thyronines have proportionately greater effects upon lowering of plasma lipids than upon general metabolic stimulation.

The present study was undertaken to (a) evaluate the effects of triiodothyronine upon plasma lipids in individuals with hyperlipidemia, (b) evaluate effects upon cholesterol synthesis in terms of rate of conversion of carbon-14 labeled mevalonic acid, and (c) evaluate rate of incorporation of C14 glucose in circulating glycerides (as an index of fatty acid synthesis from carbohydrate).

Studies were carried out in ambulatory


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