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Abstracts |

Hypokalemic Familial Periodic Paralysis.

P. J. Talso, M.D., F.A.C.P.; M. F. Glynn, M.D.; Y. T. Oester, M.D., Ph.D.; and J. Fudema, Ph.D.
Ann Intern Med. 1963;58(4):723-724. doi:10.7326/0003-4819-58-4-723_3
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A kindred in which 7 males and 2 females exhibit hypokalemic periodic paralysis has been intensively studied by chemical analyses of skeletal muscle, serial measurements of body composition, and electromyography.

In 4 individuals, biopsies of skeletal muscle were performed in the nonparalytic and paralytic states (hypokalemia and paralysis were induced with glucose and insulin). Intra- and extracellular water content was normal in the nonparalytic state; however, intracellular sodium was increased while intracellular potassium was slightly decreased. During paralysis, the volume of extracellular phase increased remarkably, while the volume of the intracellular phase was unchanged. Intracellular sodium was decreased, while intracellular

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