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Clearance from Plasma of 4-C14-Estradiol-17 Beta in Patients with Hepatic Disease.

N. P. Christy, M.D.; J. C. Shaver, M.D.; and M. S. Roginsky, M.D.
Ann Intern Med. 1963;58(4):724. doi:10.7326/0003-4819-58-4-724_1
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Two 3-μC doses of 4-C14-estradiol-17 beta were administered intravenously to each of 6 patients with normal hepatic, cardiac, and renal function, 2 patients with viral hepatitis, and 2 patients with Laennec's cirrhosis. Plasma samples were taken at 15, 30, 60, 120, and 240 minutes after injection, extracted with chloroform (85 to 99% recovery of added tritiated estradiol), and assayed for C14 radioactivity in a liquid scintillation counter. Plasma half-times of total administered radioactivity were calculated from the disappearance curves obtained; these showed no significant differences in hepatic disease without ascites (78 to 155 minutes) from normal values (105 to 145


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