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Abstracts |

Effect of Hepatocellular Injury on Gastric Secretion.

W. Silen, M.D.
Ann Intern Med. 1963;58(4):725. doi:10.7326/0003-4819-58-4-725_1
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It is well established that cirrhosis of the liver is associated with a greater incidence of peptic ulceration than that in the general population. The mechanisms by which this occurs have been unknown heretofore, particularly since controlled studies of the effect of hepatocellular injury upon gastric secretion have been unavailable. The following experiments have been carried out to elucidate some of these questions.

Hepatocellular injury has been induced in dogs equipped with denervated fundic gastric pouches by prolonged feeding of a mixture of carbon tetrachloride and alcohol. Frank cirrhosis of the liver develops in approximately 12 to 16 months in


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