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Abstracts |

The Role of the Cerebrospinal Fluid in Human Acclimatization to High Altitude.

J. W. Severinghaus, M.D.
Ann Intern Med. 1963;58(4):729. doi:10.7326/0003-4819-58-4-729_1
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Measurements of lumbar CSF during acclimatization to 3,800 m altitude in 4 normal males who live at sea level suggest that CSF pH and bicarbonate adequately represent the chemical environment of the medullary respiratory center chemoreceptor, as might be anticipated from Mitchell's recent localization of this chemoreceptor on the anterolateral surface of the medulla. The acute response to CO2 and low and high O2 was determined, permitting computation of ventilation response curves to alterations in CSF pH and alveolar Po2. This CSF pH—ventilation response curve (with PI02 = 190 mm Hg) was identical before and after acclimatization, whereas the CO


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