0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Abstracts |

Drug-induced Hemolytic Anemias.

J. H. Jandl, M.D.
Ann Intern Med. 1963;58(4):730-731. doi:10.7326/0003-4819-58-4-730_3
Text Size: A A A
This excerpt has been provided in the absence of an abstract.

Numerous chemical compounds, usually drugs, have been observed to cause hemolytic anemias. Two principal mechanisms have been elucidated: (1) an immunological disorder in which the drug behaves as a hapten or the antigen-antibody complexes fortuitously situate on the red cells; (2) a biochemical disorder in which the drug directly alters cellular metabolism. The great majority of the latter processes are caused by aromatic "redox" compounds such as phenylhydrazine, aniline compounds, quinones, and antimalarials. The anemia is characterized by the appearance of methemoglobin and Heinz bodies. The fundamental biochemical injury consists of an oxidative breakdown of cellular components by oxygen, the

...

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Related Point of Care
Topic Collections
PubMed Articles
Plexiform Pulmonary Arteriopathy in a 2 Year-Old Boy. Turk Patoloji Derg Published online Aug 11, 2014.;
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)