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Abstracts |

Drug-induced Hemolytic Anemias.

J. H. Jandl, M.D.
Ann Intern Med. 1963;58(4):730-731. doi:10.7326/0003-4819-58-4-730_3
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Numerous chemical compounds, usually drugs, have been observed to cause hemolytic anemias. Two principal mechanisms have been elucidated: (1) an immunological disorder in which the drug behaves as a hapten or the antigen-antibody complexes fortuitously situate on the red cells; (2) a biochemical disorder in which the drug directly alters cellular metabolism. The great majority of the latter processes are caused by aromatic "redox" compounds such as phenylhydrazine, aniline compounds, quinones, and antimalarials. The anemia is characterized by the appearance of methemoglobin and Heinz bodies. The fundamental biochemical injury consists of an oxidative breakdown of cellular components by oxygen, the


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