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Correlation of Erythropoietic Toxicity with the Serum Concentration of Chloramphenicol Metabolites in Patients with Renal or Hepatic Insufficiency.

L. G. Suhrland, M.D. (Associate); and A. S. Weisberger, M.D., F.A.C.P.
Ann Intern Med. 1963;58(4):731. doi:10.7326/0003-4819-58-4-731_1
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The incidence of erythropoietic toxicity due to chloramphenicol was determined in patients with renal or hepatic insufficiency and correlated with alterations in the serum concentration of chloramphenicol metabolites. Erythropoietic depression was determined on the basis of changes in serum iron, delayed appearance of Fe59 in circulating erythrocytes, and by standard hematologic examinations of peripheral blood and bone marrow.

Chloramphenicol was administered orally, 2 g daily, to 16 patients with hepatic insufficiency and to 20 patients with renal disease in chronic uremia. The incidence of erythropoietic depression was determined in these patients and compared with that observed in 15 patients with


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