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Abstracts |

The Rate of Iron Accumulation in Hemochromatosis.

W. H. Crosby, M.D., F.A.C.P.; M. Conrad Jr., MC (Associate); and M. S. Wheby, MC
Ann Intern Med. 1963;58(4):731. doi:10.7326/0003-4819-58-4-731_2
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By means of repeated phlebotomy to recover and measure the accumulated iron and by determining the rate of replenishment of hemoglobin after induced iron deficiency, it is possible to compute the rate at which iron is accumulated by absorption from the diet. Normal humans are presumed to be in iron balance and absorb iron only to replace what is lost; they accumulate none. During recovery from induced iron deficiency, a normal human accumulated iron at the rate of about 6 mg/day. Patients with hemochromatosis were found to accumulate iron at the rate of 3 to 5 mg/day. With iron deficiency,


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