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Prolonged Erythroid Aplasia in Chronic Lymphocytic Leukemia: Favorable Response to Adrenocortical Steroids in Four Cases.

J. D. Battle Jr., M.D., F.A.C.P.; J. S. Hewlett, M.D., F.A.C.P.; and G. C. Hoffman, M.B.B.Chir.
Ann Intern Med. 1963;58(4):731-732. doi:10.7326/0003-4819-58-4-731_3
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Five episodes of severe anemia and profound A reticulocytopenia associated with the virtual absence of erythroid precursors in the marrow lasting from 3 to 20 weeks were observed in 4 patients with chronic lymphocytic leukemia. A prompt resumption of erythropoiesis followed the administration of large doses of adrenocortical steroids in each patient. The direct Coombs test was positive in 2 patients, and in all 4 patients there was evidence of an active hemolytic process. Moderate hypogammaglobulinemia was present in 3 of the patients, and in one of these the administration of gamma globulin was followed by a significant but transient


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