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Penicillin Resistant Bacteria in the Mouths and Throats of Children on Continuous Prophylaxis against Rheumatic Fever.

J. G. Barrow, M.D., F.A.C.P.; and R. A. Naiman, M.D.
Ann Intern Med. 1963;58(4):735. doi:10.7326/0003-4819-58-4-735_2
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Since bacterial endocarditis caused by alpha streptococci has been shown to be a particularly serious event in the management of patients with rheumatic heart disease, and because infection with penicillin-resistant strains of alpha streptococci might well pose a therapeutic problem in treatment, an investigation comparing the mouth flora of 3 groups of individuals living free in the community was carried out. A total of 74 persons was studied, including 8 normal individuals and 66 patients of whom 45 were receiving sulfadiazine prophylaxis against rheumatic fever and 21 were receiving prophylaxis. A culture of the anterior tooth-gum margin and a culture


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