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Histoplasma Meningitis: A Study of 5 Adult Patients.

B. Tynes, M.D.; J. P. Utz, M.D., F.A.C.P.; and J. C. Crutcher, M.D. (Associate)
Ann Intern Med. 1963;58(4):737. doi:10.7326/0003-4819-58-4-737_1
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Meningitis as a manifestation of histoplasmosis has been rarely reported. In this study 5 cases are presented to define the laboratory, clinical, and therapeutic aspects of the disease.

Histoplasma capsulatum was isolated in culture from the cerebrospinal fluid of 4 patients and from the sputum of the fifth. All patients had lymphocytic meningitis with elevated protein (100 to 655 mg/100 ml), 4 had elevated spinal fluid pressure, but only 2 had depressed glucose values. Chronicity was a striking clinical manifestation with duration of illness prior to diagnosis varying from 2 months to 7 years. The spectrum of neurologic illness varied


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