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Loss of Allergenicity of Chlorogenic Acid in the Human Gastrointestinal Tract.

S. O. Freedman, M.D. (Associate); R. Shulman, M.D.; and J. H. Krupey, B.SC.
Ann Intern Med. 1963;58(4):737-738. doi:10.7326/0003-4819-58-4-737_2
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Previous studies in this laboratory have shown that chlorogenic acid, a simple phenolic compound of low molecular weight, is a major allergenic constituent of coffee bean, castor bean, and oranges. It was found, for instance, that coffee workers who developed occupational asthma or rhinitis on exposure to finely dispersed coffee dust showed positive wheal and erythema reactions to small amounts of chlorogenic acid injected intradermally. These same allergic workers were able to drink brewed coffee, which also contains chlorogenic acid, without difficulty.

The present study was designed to investigate the hypothesis that chlorogenic acid is altered or destroyed in the


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