Reports of systemic candidiasis in adults (excluding subacute monilial endocarditis) have increased markedly during the past 10 years. Experimental studies on mice performed in this laboratory and our observations on 30 patients with disseminated moniliasis, together with a review of 50 cases recorded by others, permit the following conclusions:
1. Predisposing factors include treatment with multiple antibiotics, adrenal gluco-corticoids, or both, the use of indwelling vascular catheters or needles, and probably diabetes. The most frequent manifestations are fever, tachycardia, and clinical deterioration. Severe lethargy, coma, chills, hypotension, a petechial rash, or splenomegaly occur in a minority of patients.