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G. W. Frimpter
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(Associate), New York, N. Y. (BS)

Ann Intern Med. 1963;58(4):740-741. doi:10.7326/0003-4819-58-4-740_2
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Amino acid excretion patterns were examined in 16 patients with cystinuria. Renal clearances of amino acids were studied in 4 patients. One of these demonstrated renal tubular secretion of amino acids. All patients with cystinuria excrete the asymmetrical disulfide L-cysteine and L-homocysteine. The origin of this substance from methionine was demonstrated by the administration of methionine-S35. At 1.25 hours after administration of methionine-S35, the urinary cystine and asymmetrical disulfide had a higher specific activity than later specimens. At first, the sulfur from the homocysteine and of the molecule had 9 times the specific activity of the cysteine sulfur, but later




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