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Abstracts |

Changes in Renal Function and in the Renal Circulation in Cirrhosis.

W. P. Baldus, M.D.; R. A. Feichter, M.D.; W. H. J. Summerskill, M.D.; and J. C. Hunt, M.D., F.A.C.P.
Ann Intern Med. 1963;58(4):741. doi:10.7326/0003-4819-58-4-741_2
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Azotemia of unknown cause is becoming increasingly significant as a terminal event in patients with cirrhosis who have no evidence of primary renal disease from history, urinalysis, or renal histology. Clinical observations in 25 patients indicated that azotemia preceded hypotension or oliguria and that it developed in patients with resistant ascites and poor hepatic function.

Extensive studies of renal function (clearances of inulin, PAH, creatinine, urea, sodium, potassium, water, and total osmolar substances) were therefore determined in 39 patients with cirrhosis. Progressive impairment of certain functions preceded the development of azotemia, and was related particularly to the presence and severity


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